Balevic SJ, et al. - Authors evaluated 50 pregnant females with the rheumatic disease under an observational study during the years 2013–2016 to estimate the hydroxychloroquine (HCQ) concentrations during pregnancy and correlate the levels to consequences. They observed a widely diverse HCQ concentration among women at each trimester. A significantly higher mean physician’s global assessment score value was observed in subjects with systemic lupus erythematosus (SLE). They also noticed premature deliveries in individuals with SLE (average drug levels ≤ 100 ng/ml). No linkage was found with preterm birth or disease activity in non-SLE candidates but both high and low HCQ levels were recorded correlated with preterm birth and disease activity in SLE subjects.