Gardiner SL, et al. - The clinicians used binary logistic regression to evaluate the relationship between HTT cytosine-adenine-guanine (CAG) repeat size and depression risk in 2 well-characterized Dutch cohorts: The Netherlands Study of Depression and Anxiety and the Netherlands Study of Depression in Older Persons. They revealed that repeat polymorphisms could act as hitherto unappreciated but complex genetic modifiers of depression.