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Humoral immune response to SARS-CoV-2 in Iceland

New England Journal of Medicine Sep 06, 2020

Gudbjartsson DF, Norddahl GL, Melsted P, et al. - The nature and durability of the humoral immune response to infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were determined in the population of Iceland. Researchers examined longitudinal changes in antibody levels within the first 4 months after SARS-CoV-2 infection. Using six different assays, they determined SARS-Cov-2 reactive serum antibodies in two groups of qPCR-positive persons and six groups of persons who had not been tested with qPCR or who had been tested and received negative results. Outcomes suggest no decline in antiviral antibodies against SARS-CoV-2 within 4 months after diagnosis. Per estimates, the infection had mortality risk of 0.3% and there were 44% of persons infected with SARS-CoV-2 in Iceland who were not diagnosed by qPCR.

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