Lains I, et al. - The plasma metabolomic profile of patients with age-related macular degeneration (AMD) utilizing mass spectrometry (MS) is described in this study. The outcome of this study suggests that participants with AMD have altered plasma metabolomic profiles compared with controls. This information proposes that the most significant metabolites map to the glycerophospholipid pathway. These outcomes have the potential to improve their comprehension of AMD pathogenesis, to support the development of plasma-based metabolomics biomarkers of AMD, and to identify novel targets for treatment of this blinding disease.