Guleria C, et al. - Since HPV represents a recognized causative factor of cervical cancer and interferes with the expression of TLRs and downstream signaling pathway, researchers analyzed cervical squamous cell carcinoma (CSCC) and normal cervical tissues in this study to determine the relative gene expression of TLRs & downstream signaling pathway in cervical carcinoma. In HR-HPV infected cervix, they found significant upregulation of TLR4 and downregulation of TLR2,7. Upregulation of RELA, AKT, CDKN2A, and MDM2 (molecules from cancer allied pathways) was identified in CSCC. Poor prognosis in correlation to high TLR4 and low TLR7 expression was shown by the Kaplan Meier curve. In CSCC, innate immune response dampening mediated by HPV was shown in this study. Also, the exploration of potential TLR2, 7 agonists as an adjunct therapy in CSCC patients was supported.