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Human leukocyte antigen DQ2/DQ8 positivity in women with history of stillbirth

American Journal of Reproductive Immunology Aug 24, 2018

Cozzolino M, et al. - Women with previous stillbirth, but not affected by celiac disease (CD), were investigated for the prevalence of human leukocyte antigens (HLA) DQ2 and DQ8 haplotypes, which are two common polymorphisms associated with CD. Researchers enrolled women with history of unexplained term stillbirth (referred to their Center for High-Risk Pregnancies for a preconception counseling) and women with previous uncomplicated pregnancies, as cases and controls. Compared to women with previous uneventful pregnancies, women with history of term stillbirth showed a significantly higher prevalence of HLA DQ2/DQ8 haplotypes. In addition, there was a significant association between HLA DQ2/DQ8 positivity and suboptimal fetal growth in intrauterine fetal death cases, as indicated by an increased prevalence of SGA babies.

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