Ma KSK, Chung WH, Hsueh YJ, et al. - In the present study, the researchers sought to examine the human leucocyte antigen (HLA) polymorphism pattern in cold medicine (CM)-induced patients with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) developing severe ocular complications (SOCs). All participants, including SJS/TEN patients (n = 33) and control patients (n = 98), were enrolled from 2016 to 2017 via clinic visits. SOCs were diagnosed (n = 26) through a chart review or eye examination. The HLA-A*02:07 and HLA-B*46:01 alleles among Han Chinese patients with CM-SJS/TEN were significantly correlated with SOCs. The genetic diversity in SJS pathogenesis among various ethnic groups is demonstrated by these findings.