Ji Q, et al. - This study assessed patients with coronary artery disease (CAD) for human epicardial adipose tissue (EAT)-derived and circulating secreted frizzled-related protein 4 (SFRP4) levels. These patients exhibited increased EAT-derived and circulating SFRP4 expression levels. Findings also demonstrated that EAT SFRP4 mRNA levels and plasma SFRP4 concentrations were independently related to the presence of CAD.