Das B, et al. - Researchers assessed the impact of Dorsal Root Ganglion (DRG) Pulsed radiofrequency (PRF) treatment on lymphocyte frequencies and secreted inflammatory markers in the cerebrospinal fluid (CSF) in patients with radicular pain. Furthermore, they correlated this with clinical outcome to determine clinical markers of chronic radicular pain. Findings lend support to the concept that chronic radicular pain is a centrally mediated neuroimmune phenomenon and the mechanism of action of DRG PRF treatment is immunomodulatory.