Bartel S, La Grutta S, Cilluffo G, et al. - Given that signaling pathways critically implicated in asthma are chiefly regulated by microRNAs (miRNA), which are transferred between cells in extracellular vesicles (EV), researchers determined if asthma development is accompanied by changes in miRNA content of EV secreted by primary normal human bronchial epithelial cells. This study included 8 children with mild-to-moderate asthma, 9 with severe asthma, and 9 healthy controls. Significant correlation of levels of miR-92b, miR-210, and miR-34a with lung function parameters in children was found and therefore, lower small EV (50-150 nm)-miRNA levels in nasal lavages related to airway obstruction. Overall, the possible implication of miRNAs secretion in EVs from the airway epithelium, specifically miR-34a, miR-92b, and miR-210, in the early development of a Th2 response in the airways and asthma was indicated.