HSD3B1 and response to a nonsteroidal CYP17A1 inhibitor in castration-resistant prostate cancer
JAMA Oncology Oct 26, 2017
Almassi N, et al. - The objective of this study is to figure out if the HSD3B1 (1245C) genotype is predictive of clinical response to extragonadal androgen ablation with nonsteroidal 17α-hydroxylase/17,20-lyase (CYP17A1) inhibition in men with metastatic castration-resistant prostate cancer (CRPC). Inheritance of the HSD3B1 (1245C) variant allele, which is a predictive biomarker of resistance to castration, is also a predictive biomarker of sensitivity to extragonadal androgen ablation with a nonsteroidal CYP17A1 inhibitor. For patients with prostate cancer, these outcomes signal a possible pathway of treatment stratification.
Go to Original
Only Doctors with an M3 India account can read this article. Sign up for free or login with your existing account.
4 reasons why Doctors love M3 India
-
Exclusive Write-ups & Webinars by KOLs
-
Daily Quiz by specialty
-
Paid Market Research Surveys
-
Case discussions, News & Journals' summaries