Wotman M, et al. - Researchers conducted this investigation to examine the etiologic and prognostic role of human papilloma virus (HPV) in nasopharyngeal carcinoma (NPC). The Surveillance, Epidemiology and End Results (SEER) database identified patients diagnosed with NPC. They used logistic regression to examine the impact of clinicopathologic predictors on HPV positivity in NPC. Findings revealed that positive results for HPV-associated NPC were seen in 180/517 subjects with known HPV testing. While controlling for AJCC-7 stage and AJCC-7 M stage, East Asians and people over 25 were found to be less likely to have NPC associated with HPV. According to the survival analysis, cause-specific survival throughout the study period did not vary considerably by HPV status but substantially differed by ethnicity group of HPV. The clinical implications of HPV in NPC are further clarified, but more research is required.