Pepe P, et al. - From January 2016 to June 2019, 875 men underwent repeat saturation biopsy (SPBx) for the suspicion of cancer in order to assess the number of needle cores combined with multiparametric MRI (mpMRI) findings required to diagnose all clinically important cases of prostate cancer (csPCa) in men subjected to transperineal SPBx (30 cores). All cases of csPCa were identified by a maximum of 20 systematic transperineal needle cores in men subject to mpMRI and/or TPBx and it reduced the diagnosis of indolent cancers.