Singh JA, et al. - This study attempted to examine the incidence, time trends, and outcomes of serious infections in people with osteoarthritis (OA). Researchers applied 1998–2016 US National Inpatient Sample data. The epidemiology of 5 types of serious infections requiring hospitalization in people with OA was examined using recommended weights (opportunistic infections, skin and soft tissue infections, urinary tract infections, pneumonia, and sepsis/bacteremia). Multivariable-adjusted logistic regression analyses were conducted to examine factors associated with healthcare utilization (hospital charges, length of hospital stay, discharge to non home setting), and in-hospital mortality. It has been reported that serious infection rates have increased in people with OA. Relationship of demographic, clinic, and hospital variables with serious infection outcomes distinguishes potential targets for further trials.