Gordhandas S, et al. - In this article, researchers reviewed literature on hormone replacement therapy (HRT) in BRCA mutation carriers undergoing risk-reducing salpingo-oophorectomy (RRSO), including effects on quality of life, and cardiovascular, bone, and brain health. Findings revealed improved endocrine symptoms and sexual function after premature surgical menopause using HRT. Estrogen replacement therapy after oophorectomy led to no alteration in breast cancer risk in BRCA mutation carriers. A less favorable breast cancer risk profile was evident with progestin containing hormonal regimens for BRCA mutation carriers.