Hollis RL, Stanley B, Iida Y, et al. - Researchers used histoscore (a nuclear scoring method including both proportion of positive cells and the intensity of nuclear staining) to evaluate expression levels of progesterone receptor (PR), estrogen receptor alpha (ER) and androgen receptor (AR) across a cohort of 107 WT1 negative endometrioid ovarian carcinomas (OCs)[EnOC]. Four EnOC subgroups were discovered via hierarchical clustering by PR, ER and AR histoscores: PR+/ER+, PR+/ER−, PR−/ER+ and PR−/ER−. Favorable outcome was seen in EnOC patients in the PR+/ER+ and PR+/ER− groups vs the PR−/ER+ group. The observed 10-year survival for stage II PR^high cases was 94.1% and for PR^low cases was 42.4%. Higher body mass index was detected in ER^high EnOC patients (PR+/ER+, PR−/ER+) vs ER^low cases and high grade serous OC patients. In this study, markedly favorable outcome was experienced by patients with EnOC with high PR expression. Stage II EnOCs with high PR expression were identified as potential candidates for de-escalation of first-line treatment.