Irizarry KA, et al. - Candidates were randomized by investigators to assess the hormonal and metabolic consequences of carbohydrate restriction in children with Prader-Willi syndrome (PWS). They compared fasting and postprandial concentrations of hormones and metabolites in 8 PWS kids (age 9-18 years) fed randomly on low carbohydrate, high-fat (LC, 15% carb; 65% fat; 20% protein) and low-fat, high carbohydrate (LF, 65% carb, 15% fat, 20% protein) diets matched for calories and protein. They observed an improvement in glycaemic control when inclined GLP-1 with low carbohydrate feed was given. They noted the similar consequences with a reduced ratio of ghrelin to GLP-1.