Wainberg M, Mahajan A, Kundaje A, et al. - Given the established beneficial effect of weight-loss interventions for type 2 diabetes prevention in high-risk and prediabetic individuals, researchers investigated if the same benefits apply to those at a lower risk. They investigated inherited genetic mutations that predispose people to lower body weight and determined the protective effect of these mutations among people with type 2 diabetes, across 287,394 self-reported white British individuals from the UK Biobank cohort. As per the analysis, these mutations appear to provide the same degree of protection against type 2 diabetes irrespective of a person’s body weight, family history of type 2 diabetes, or genetic risk for type 2 diabetes. Findings imply that among all individuals, weight loss would have a correspondingly uniform protective effect against the type 2 diabetes risk, supporting the broad deployment of weight-loss interventions to individuals at all levels of diabetes risk as a public health measure.