Farina N, et al. - The connection amongst hyperhomocystenemia and relevant vitamins as the disease progress are investigated in this study. This study suggests that the increase in homocysteine seen in Alzheimer's disease (AD) patients as the disease progresses cannot be solely clarified by dietary and blood levels of folate and vitamin B12. Other dietary and non-dietary factors may contribute to hyperhomocysteinemia and its toxic impact in AD, which should be investigated to optimise timely intervention strategies.