Xu J, et al. - Researchers analyzed studies reporting the association between homocysteine and digestive tract cancer risk. These studies were identified from PubMed, Embase, Cochrane, and Web of Science databases, via comprehensive searches performed up to September 25, 2018. The strength of the above-mentioned link was assessed using odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs). Overall, 13 studies were included in the meta-analysis. For patients with the highest categories of blood homocysteine levels vs the lowest categories, the pooled OR was 1.27 for digestive tract cancer risk, with no significant heterogeneity observed. The incidence of digestive tract cancer was increased by 7%, with each 5μmol/L increase in homocysteine. Overall, a higher risk of digestive tract cancer was observed in relation to elevated homocysteine, and homocysteine concentration could serve as a potential biomarker for occurrence of digestive tract cancer.