Fujii H, et al. - Researchers conducted this study to assess the utility of the homeostasis model assessment parameter of insulin resistance (HOMA-IR), an index of insulin resistance (IR) and one of the most important metabolic factors, as a predictive factor for advanced fibrosis in nondiabetic patients with nonalcoholic fatty liver disease (NAFLD). This retrospective, cross-sectional multicenter trial including 361 patients with biopsy-proven NAFLD who had not received a diagnosis of type 2 diabetes mellitus. According to findings, HOMA-IR was an independent predictor of advanced liver fibrosis in nondiabetic patients with NAFLD. Because the majority of patients with NAFLD are nondiabetic, the authors recommended setting goals with regard to improving IR to subsequently reduce liver fibrosis.