Schwartz SR, et al. - Researchers conducted this prospective cohort study enrolling adults at least 18 years old in relationships with an HIV-positive partner who were trying to conceive in the Sakh'umndeni, a novel safer conception service in South Africa, to assess safer conception methods and HIV and pregnancy outcomes from Sakh'umndeni. They enrolled 526 individuals (334 women and 192 men) from 334 partnerships. Nurses provided safer conception care to the participants, which included antiretroviral therapy for HIV-positive partners, pre-exposure prophylaxis for HIV-negative partners, counseling around timed condomless sex, or syringes for self-insemination. Outcomes suggest that couples were empowered to safely conceive with safer conception strategies. Among service users, they noted a high incidence of pregnancy. HIV prevention and linkage to care could be promoted via integration of safer conception counseling.