Farhadian S, et al. - Given the persistence of changes in immune phenotype and function in individuals with chronic HIV despite major progress in controlling HIV disease through antiretroviral therapy, researchers evaluated the impact of HIV serostatus and age on T-cell phenotypes (expressed as percentages of the total CD4+ and CD8+ T-cell population) using multivariate linear regression, adjusted for smoking, alcohol, and race/ethnicity. Findings suggested that age and HIV status independently altered the immune system. However, no conclusive evidence suggested that HIV infection and advancing age synergistically result in accelerated changes in age-associated T-cell markers among virally suppressed individuals.