De Vito C, et al. - Researchers assesses the histological changes in livers of patients with congenital portosystemic shunt (CPSS). They reviewed the liver histology of 22 consecutive patients managed between 2001 and 2016. In most samples from the pediatric patients, physiological nuclear vacuolation of periportal hepatocytes was absent. The most characteristic histological changes of CPSS in the liver periphery are the presence of prominent thin-walled channels (PTWCs), arterial-biliary dyads, increased arterial profiles in portal tracts and lobule and lack of the physiological periportal vacuolated hepatocytes in children.