van Houdt PJ, Ghobadi G, Schoots IG, et al. - Considering the previous works reporting underestimation of tumor volume with multiparametric (mp)MRI in prostate cancer diagnosis, researchers examined why some parts of lesions are not visible on mpMRI via assessing their histopathology features vs those of visible regions. They included 34 patients with biopsy-proven prostate cancer scheduled for prostatectomy (median 68.7 years) in this work. Suspicious lesions on mpMRI were delineated by two readers. The lesions were delineated on histopathology by a pathologist. The analysis revealed more frequent missing of small, anterior, and International Society of Urological Pathology (ISUP) grade 1–2 lesions (n = 34) vs large, posterior, ISUP grade ≥ 3 lesions (n = 35). Lesions with lower tumor density, heterogeneous tumor morphology, and location in the transition zone, were invisible on mpMRI. These findings may improve monitoring during active surveillance and focal treatment strategies.