Bhalla A, et al. – This study comprised of a histopathological analysis of the neoplastic progression of von Meyenburg complex (VMC) to intrahepatic cholangiocarcinoma (iCC). The data revealed that non–VMC–associated iCCs were moderately to poorly differentiated with solid, cribriform or papillary growth patterns. They possibly dispalyed necrosis, perineural invasion, positive surgical margin, lymphovascular invasion, and high T stage. Ki67 and p53 immunostains supported the persistent neoplastic evolution from benign VMC to dysplasia and then to iCC. It was found that VMC could become neoplastic. It served as an in–situ carcinoma lesion to transform to iCC. The underlying molecular alteration and clinical implication of this neoplastic transformation warranted advanced analysis.