Kobayashi M, et al. - Researchers report results from a national colorectal cancer (CRC) screening program, which is an international collaboration between Japan and Chile, that started in Chile in 2012 and was based on a standardized protocol supported by Tokyo Medical and Dental University. Outcomes from the first 2 years of screening at one public hospital are presented in this study. They detected lesions in 291 of 485 participants (having immunological fecal occult blood test values of at least 100 ng/ml and/or those with family histories of CRC) who were asked to undergo colonoscopy. Overall 642 histologic samples were taken. A diagnosis of adenocarcinomas was received by 60/291 participants (20.6%). Of these, 50 (83.3%) were early-phase adenocarcinomas (pTis or pT1), and conventional adenomas were detected in 163 (56.0%), of which high-risk adenomas were 96 (58.9%). Within the screened population, 1.5% (60 of 4124) was estimated to be the cancer prevalence. The histopathologic distributions of consecutive lesions, as well as the high incidence of CRC in Chile, was shown for the first time ever. Findings suggest that early CRC screening is feasible as well as has the potential to decrease the death related to CRC, as supported by the observed high detection rates for high-risk adenomas and cancer in this study.