Corbella S, et al. - This systematic review purposefully determined which material is the most effective bone substitute for alveolar bone healing by evaluating histomorphometric outcomes after healing of postextraction sockets in humans. In terms of new bone formation, there was no evidence for the superiority of a given biomaterial over the others. While calcium sulphate and beta-tricalcium phosphate resorbed faster than other biomaterials, xenografts exhibited a lower resorption rate than allografts. Comparative studies recommended that bovine bone was related to a lower proportion of new bone volume compared to sites left to heal spontaneously, on the other hand, porcine bone and magnesium-enriched hydroxyapatite were related to higher new bone volume. Findings revealed that allograft was not related to higher new bone volume than sites healed without any biomaterial.