Li Q, Li X, Li XY, et al. - For assessing the histological subtypes of solid-dominant invasive lung adenocarcinoma (SILADC), this study was conducted to explore the value of dual-energy spectral computed tomography (DESCT). Researchers included a total of 67 patients with SILADC. All patients had undergone DESCT and were classified into those with a lepidic/acinar/papillary predominant pattern (Group I ) and those with a solid/micropapillary predominant pattern (Group II) based on their correlation with prognosis. There were significant differences seen between both groups in DESCT morphological features including tumor size, necrosis, calcification, air bronchogram, and vascular convergence sign, and quantitative parameters including K 40–65 keV, effective atomic number, and water concentration on unenhanced CT and iodine concentration in the arterial and venous phases. Tumor size, air bronchogram, K 40–65 keV and effective atomic number on unenhanced CT were the most effective variations for predicting the histological subtypes of SILADC and obtained an area under the ROC curve (AUC) of 0.906 in multiparametric analysis. DESCT was able to discriminate between histological subtypes with different prognosis of SILADC