Pan XX, et al. - Based on the Surveillance, Epidemiology, and End Results (SEER) Program, researchers assessed the influence of histological subtype on survival in nasopharyngeal carcinoma (NPC) individuals. NPC patients were identified within the SEER database (2004–2015). Using univariate and multivariate Cox regression analyses, the impacts of histological subtype on cause-specific survival (CSS) in NPC patients were assessed. In total, 4,085 NPC patients were chosen from the SEER database, involving 1,929 with keratinizing squamous cell carcinoma (KSCC), 2,203 with nonkeratinizing carcinoma (NKC), and 53 with basaloid squamous cell carcinoma (BSCC). Data reported that the 3-year and 5-year CSS rates for KSCC patients were 61.76% and 55.07%, for NKC patients 79.57% and 72.09%, and for BSCC patients 77.55% and 74.03%, respectively. Histological subtype determines the long-term outcomes for the survival of NPC patients. The NKC subtype also has the best prognosis while the KSCC subtype has the worst prognosis. In NPC patients, multivariate analysis identified gender, age, marital status, race, T stage, N stage, M stage, radiotherapy, chemotherapy, and histological subtype as significant prognostic factors for CSS.