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Histogram analysis of diffusion kurtosis imaging based on whole-volume images of breast lesions

Journal of Magnetic Resonance Imaging Aug 11, 2019

Li T, et al. - Via a retrospective study of 120 patients with breast lesions (62 malignant, 58 benign), researchers examined the performance of whole-volume histogram parameters derived from a diffusion kurtosis imaging (DKI) model for distinguishing benign and malignant breast lesions. The highest area under the curve, sensitivity, and accuracy was noted in Kmax, Dmin, and apparent diffusion coefficient (ADC)min in their individual histogram parameter groups and Kmax was discovered to outperform Dmin and ADCmin. In all groups, ADC histogram parameters (from ADCmin to ADCsd) were significantly lesser in comparison with D histogram parameters. For distinguishing benign from malignant tumors, Kmax, Dmin, and ADCmin were observed to be better metrics as that of the corresponding average values. In contrast with ADC parameters derived from the diffusion-weighted imaging model, histogram parameters derived from the DKI model gave more information and had better diagnostic performance.
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