Lavdas I, et al. - In this single-institution prospective study, the researchers estimated apparent diffusion coefficient (ADC) histogram analysis parameters, acquired from whole-body diffusion-weighted magnetic resonance imaging (DW-MRI), as very early predictors of response to chemotherapy in patients with metastatic colorectal cancer (mCRC). Prior to imaging, all patients gave fully informed consent. They reported that ADC histogram analysis reveals potential in discriminating progressive from non-progressive disease in patients with mCRC, who underwent whole-body DW-MRI. Results of this study suggested that the technique can potentially be tested as a response assessment methodology in larger trials.