Meyer HJ, et al. - Thirty individuals with histologically proven head and neck squamous cell carcinomas (HNSCC) were involved in the study in order to clarify possible correlations between microvessel density and histogram parameters in HNSCC. Median derived from K^trans associated with vessel area. No other K_trans or V_e parameter reached statistically importance. Various K_ep derived parameters associated with vessel area as well as with vessel count. The highest correlation coefficient with the vessel area was noted in MinK_ep. The highest coefficient with vessel count was discovered in ModeK_ep. Thus, in HNSCC, histogram parameters derived from K_ep might be utilized as the alternative imaging biomarkers for the microvessel density parameter. Moreover, MinimumK_ep exhibited the highest correlation with vessel area and Mode K_ep with vessel count.