Ding Y, et al. – Researchers here aimed at investigating the prevalence and correlates of prefrailty/frailty, determined on the basis of the Fried criteria, in Chinese patients with and those without human immunodeficiency virus (HIV) infection. Findings suggested that neurocognitive impairment and depressive and/or insomnia symptoms could account for a higher prevalence of prefrailty/frailty in HIV–infected patients but require further longitudinal investigation.

• Observations revealed that in comparison to controls, HIV–infected patients were more likely to be frail or prefrail, and this association remained significant after adjustment for potential confounders (odds ratio, 3.79).
• After additional adjustment for neurocognitive impairment and depressive and insomnia symptoms, this association remained significant but attenuated (odds ratio, 2.16).
• These 3 variables seemed independently associated with prefrailty/frailty in the HIV–infected group.