Gulhati V, et al. - Given the possible correlation of systemic inflammation, platelet dysfunction, and endothelial activation, that persist in people living with HIV despite sustained virologic suppression (SVS) with combined antiretroviral therapy (cART), with complications such as atherosclerosis and cardiovascular disease, researchers studied angiopoietin-1 (Ang-1), a key regulator of angiogenesis and endothelial activation, in 61 children living with vertically acquired HIV on cART with undetectable RNA viral load, to assess its relation to clinical characteristics. Outcomes revealed a direct correlation of Ang-1 levels with clinical indices of virologic control. Higher Ang-1 levels were noted in correlation with early effective cART and SVS in children living with vertically acquired HIV-1.