Chao WC, et al. - As critically ill patients frequently exhibit high glycemic variability (GV), researchers sought to determine the prevalence and mortality association with early GV in patients with sepsis. In a medical intensive care unit (ICU) in central Taiwan, they conducted a retrospective cohort study of 452 patients with sepsis (mean age 71.4 ± 14.7 years; 76.7% men) between January 2014 and December 2015. Protocol-based management, including blood sugar monitoring every 2 h for the first 24 h of ICU admission, was undertaken in all of these patients. Observations revealed a high early GV (defined as the mean amplitude of glycemic excursions > 65 mg/dL) in nearly 40% of the septic patients. They identified an independent association of higher GV within 24 h of ICU admission with increased 30-day mortality. This emphasizes undertaking monitoring GV in septic patients early during ICU admission.