Gade C, et al. - Experts tested the in vivo activity of Cytochrome P450 (CYP) 2E1 in obese children compared to nonobese children, aged 11–18 years. They also assessed whether the activity of CYP2E1 in these patients is related to NALFD, diabetes or hyperlipidaemia. Compared to nonobese children, there was a two-fold increase in oral clearance of chlorzoxazone (CLZ) in obese children aged 11–18 years. An increased CYP2E1 activity of clinical importance was suggested. Findings suggested consideration of dose adjustment for CLZ.