McKeever L, Peterson SJ, Lateef O, et al. - Among 35 critically ill patients, researchers analyzed the influence of calorie exposure on nonthyroidal illness syndrome (NTIS) over time. For this investigation, they randomized mechanically ventilated individuals with systemic inflammatory response syndrome to receive either 100% or 40% of their estimated caloric needs. For seven days or until intensive care unit discharge or death, thyroid hormones were measured daily. According to findings, higher caloric intake in NTIS patients transiently mitigates the decrease in the T3/rT3 plasma ratio, an impact that is reduced and ultimately lost over the next 3 days of continued higher caloric exposure.