Sadraei NH, et al. - In this retrospective analysis of 119 patients with advanced non-small-cell-lung-cancer (NSCLC) treated with pemetrexed between 2004 and 2011, the ability of two proteins involved in DNA repair mechanisms, uracil DNA glycosylase (UDG) and BRCA1 to be potential prognostic biomarkers was evaluated. Researchers analyzed formalin-fixed-paraffin-embedded tumor specimens from these patients. Findings demonstrated high UDG expression had an important prognostic role in pemetrexed-treated NSCLC patients, in addition to its previously reported role in pemetrexed cytotoxicity. Shorter progression-free (PFS) and overall survival (OS) were predicted by high UDG expression. They noted the poorest outcome following pemetrexed treatment patients with a combined profile of UDG^high/BRCA1^high.