Nam KW, et al. - Among 3,172 neurologically healthy participants, researchers assessed the connection between triglycerides (TG)/high-density lipoprotein (HDL) cholesterol ratio and the presence of silent brain infarct (SBI) SBI was defined as an asymptomatic, well-defined lesion with a diameter of ≥3 mm on T1- or T2-weighted images. From January 2006 to December 2013, the authors retrospectively assessed consecutive participants in health check-ups. Of al the participants, 8.3% had SBI lesions. The TG/HDL cholesterol ratio was positively correlated in the analyses of the links between lipid parameters and SBI lesion burden, and total cholesterol/TG ratio was negatively related to SBI lesion burden in dose-response manners. In a neurologically healthy population, the TG/HDL cholesterol ratio was positively linked to the prevalence of SBI. In males, this association was prominent, but not in females.