Liu Y, et al. - Since squalene epoxidase (SQLE) is considered a metabolic oncogene, but its biological function and prognostic value in head and neck squamous cell carcinoma (HNSCC) are unknown, researchers used bioinformatics analysis and validation experiments to assess SQLE's role in the occurrence and development of HNSCC. Using Gene Expression Omnibus datasets and immunohistochemistry, SQLE expression in HNSCC was assessed. SQLE was found to be overexpressed and amplified in a variety of cancers, including HNSCC. In HNSCC patients, high SQLE expression promoted cell proliferation and was associated with the T stage. SQLE was discovered to be a prognostic biomarker as well as a potential pharmaceutical target for HNSCC.