High-sensitivity C-reactive protein and the risk of chronic kidney disease progression or acute kidney injury in postmyocardial infarction patients
American Heart Journal Aug 07, 2019
Fu EL, Franko MA, Obergfell A, et al. - Researchers assessed high-sensitivity C-reactive protein (hsCRP) levels as a predictor of adverse renal outcomes in myocardial infarction (MI) survivors. The participants were undergoing hsCRP testing > 30 days following an MI episode during routine healthcare in Stockholm, Sweden (2006-2011). The information regarding the estimated glomerular filtration rate was available for these individuals. Chronic kidney disease (CKD) progression (composite of doubling plasma creatinine, renal replacement therapy, or renal death) and acute kidney injury (AKI, acute creatinine peaks by Kidney Disease: Improving Global Outcomes criteria) were evaluated as outcomes. A total of 12,905 patients were included; 35% of them had an eGFR<60 mL/min/1.73 m2. Regardless of baseline kidney function, the subsequent risk of AKI and CKD progression was observed in relation to elevated hsCRP in post-MI patients undergoing routine healthcare. Patients with hsCRP ≥2 mg/L were at higher risk of both CKD progression and AKI vs those with hsCRP <2 mg/L.
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