High-sensitivity C-reactive protein and the risk of chronic kidney disease progression or acute kidney injury in post-myocardial infarction patients
American Heart Journal Jul 10, 2019
Fu EL, et al. - In order to determine if adverse renal outcomes in patients with cardiovascular disease can be predicted by high-sensitivity C-reactive protein (hsCRP) levels, researchers performed this study with myocardial infarction (MI) survivors undergoing hsCRP testing >30 days following their MI during routine healthcare in Stockholm, Sweden (2006–2011). The participants had data available on the estimated glomerular filtration rate (eGFR). Patients with ongoing/recent cancer, chronic infections or immunosuppression as well as HsCRP tests measured during hospitalization/emergency room visits, followed by antibiotics or suggestive of acute illness were rejected. This study included 12,905 patients (62% men, mean age 73 years and 3 years since MI), with an eGFR<60 ml/min/1.73m2 in 35%. Findings revealed the association of elevated hsCRP with subsequent risk of acute kidney injury and progression of chronic kidney disease, regardless of baseline kidney function, among post-MI patients undergoing routine healthcare.
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