High-sensitive cardiac troponin T as a marker of hemorrhagic complications in elderly patients anticoagulated for non-massive pulmonary embolism
Thrombosis Research Nov 15, 2019
Simona A, Limacher A, Méan M, et al. - A total of 230 old people with an available blood sample obtained within one day from diagnosis were assessed in order to ascertain the prognostic exactitude of hs-cTnT, NT-proBNP, RIETE and PESI score for the occurrence of clinically relevant bleeding (CRB) in old people under conventional anticoagulation therapy for non-massive pulmonary embolism (NMPE). The highest discriminatory power at 1 month was illustrated by hs-cTnT which continued to be stable over time. However, the C-statistics comparison showed that hs-cTnT was not statistically better than the RIETE score, adding hs-cTnT to RIETE score notably enhanced the C-statistics. SHRs designated that for each hs-cTnT log-unit rise, irrespective of the RIETE score, a 58% rise in the risk of CRB was noted. Thus, in old people, to recognize NMPE individuals at low risk of bleeding, hs-cTnT provides incremental prognostic information over the RIETE score and could designate as a valuable tool.
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