Tang KD, et al. - researchers examined the salivary oral rinse and unstimulated whole mouth saliva samples of 45 subjects with oropharyngeal cancer (OPC) to evaluate the use of salivary oral rinse as a diagnostic fluid in the detection of oral human papillomavirus (HPV) DNA. In both sample methods, a positive association of HPV-16 E2 and E6/7 relative copy number, as well as HPV genotypes, was observed. They also found a significant relationship between the two sample methods in the ratio of HPV16 E2 to E6/7 DNA. In both saliva and tumor samples, a mixed HPV-16 form (episomal and integrated) was commonly detected. They found comparable results while detecting HPV in saliva samples collected by either method and exhibited good sensitivity for the detection of HPV derived from OPC.