Rengarajan A, et al. - In predicting abnormal reflux burden, researchers determined the impact of high-resolution manometry (HRM)-based esophagogastric junction (EGJ) and lower esophageal sphincter (LES) metrics. Out of ambulatory reflux monitoring performed off therapy in 482 patients, total, upright and supine acid exposure times (AETs) were extracted. To determine the value of HRM parameters in predicting abnormal esophageal reflux burden, univariate and multivariate analyses were performed. Findings revealed that HRM-based EGJ morphology and EGJ barrier assessment independently predict esophageal reflux burden.