Alvarez AL, et al. - Researchers investigated the rate of malignancy in patients with hyperthyroidism who have undergone thyroidectomy. They analyzed data of 138 patients with hyperthyroidism who underwent thyroidectomy and divided them into three groups: Graves’ disease (n = 80), toxic multinodular goiter (n = 46), and toxic solitary nodule (n = 12). Malignancy on final pathology was reported in 22% of 138 patients. This indicates a clinically significant rate of malignancy in these patients. The highest rates of malignancy were noted among patients with distinct thyroid nodules in the presence of hyperthyroidism and hence appropriate workup with ultrasound and fine-needle aspiration (FNA) is recommended in these patients to exclude underlying malignancy. They suggest considering surgical treatment as initial management in cases with suspicious ultrasound features and/or FNA cytopathology.