Braun DL, et al. - Researchers here aimed to determine the risk factors of individuals with an asymptomatic sexually transmitted infection (STI) for the implementation of targeted STI screening strategies. For this work. all participants in the Zurich Primary human immunodeficiency virus (HIV)-1 Infection study were offered an STI screening. Observations revealed that compared with presenting in the chronic phase, presenting with a primary HIV infection was associated with higher odds for later risky sexual behavior. STIs had a high period prevalence of 33.3%. Sixty-six percent of patients were asymptomatic. Engaging in insertive or both insertive and receptive anal intercourse, STI symptoms, and condomless sex were observed to have a positive correlation with a positive screening result in a multivariable model. Researchers recommended considering a trimonthly STI screening including asymptomatic individuals in this population, particularly in MSM who report sexual risk behavior.