Spence AD, et al. - Researchers performed a cohort study of 135 patients with oesophageal adenocarcinoma who received neoadjuvant chemotherapy and surgery from 2004 to 2012 in the Northern Ireland Cancer Centre to investigate the association between prostaglandin endoperoxide synthase-2 (PTGS2) expression and prognosis in these patients. In contrast to previous evidence, findings of this work revealed improved overall and cancer-specific survival in correlation with high PTGS2 expression in oesophageal adenocarcinoma tissue. As this is the first study of its kind to include patients who had undergone neoadjuvant chemotherapy, they recommend performing further studies to clarify these associations.