Li C, Birmaher B, Rooks B, et al. - Researchers investigated the prevalence of metabolic syndrome (MetS) and important clinical correlates of MetS among adolescents and young adults (mean ± SD age = 20.8 ± 3.7 years; range, 13.6–28.3 years) with bipolar disorder (I, II, or not otherwise specified, based on DSM-IV) enrolled in the Course and Outcome of Bipolar Youth (COBY) study between 2000 and 2006. The analysis revealed MetS prevalence of 19.8% (32/162) in this sample, suggesting that this sample had at least double prevalence than the general population. The most common MetS criteria were low HDL-C (56.5%) and abdominal obesity (46.9%). A nominal association was observed between MetS and lower lifetime global functioning at COBY intake. Furthermore, this group displayed an increased burden of depression symptoms in correlation with MetS. They recommend integrating strategies focused on modifying MetS risk factors in the management of early-onset bipolar disorder.​